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Front Page · Everything · News · Ask Guppylog · Diaries
Levamisole Hydrochloride killed our fish

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By Katastic01, Section Ask Guppylog
Posted on Wed Aug 29, 2007 at 12:33:51 PM PST
Tags: (all tags)
I medicated our fish per the instructions found on this site and others.  Now our fish are dead/dying.  What happened and what can I do?



[editor's note, by Scott Lockwood] Everyone should read this. This is why, if you are at all unsure about how to dose your fish, consult a professional. Overdosing your fish with the right medication is as bad as the disease.

We have been searching this site for about a week now, trying to figure out what is wrong with our fish.  We now know they are suffering with camallanus.  We ordered the Levamisole Hydrochloride made by AgriLabs (52g package, 46.8g of medication).  It's also called Prohibit on the package.  I followed the instructions posted on this site (I think).  I put 2 grams in a 30 gallon tank after cleaning the tank really well.  After eating lunch, I checked on the fish (about 30 minutes from treating to checking) 8 of them were dead.  I have a combination of guppies, tetras, barbs and some bottom feeders.  All of the tetras and barbs are dead, along with a couple of bottom feeding shark-like fish (inherited most of the fish in this tank, can't find out what some are).  When I found them, all of the fish were a dark, almost black, very stressed color.  I took the survivors out before they suffered too much, I hope.  One guppy was belly up but still breathing when I found them but seems to be doing okay now.  The fish are still dark in color, several hours later.  Two more have died.  Please help.

I appreciate your time.

Katastic01

< Treating Camellanus with Levamisole Hydrochloride | the guppy that I tried to help died anyway... >
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Levamisole Hydrochloride killed our fish | 23 comments (23 topical, 0 editorial, 0 hidden)
Re: Levamisole Hydrochloride killed our fish (none / 0) (#15)
by inkmaker on Wed Apr 25, 2007 at 08:21:14 PM PST

<H2>The loss of the small fishes is regreatable but I must suggest the situation is not all that uncommon. Getting the dead parasite out of the infested fish is a big problem for the fish. I plan to post pictures from treatments this weekend.
<BR>
A recent email follows:</H2>
~~~~~~~~~~~~~~~~

Well then, Great news!

The major thing at this point is to get the dead worms out of the fish. They actually freeze and are paralyzed by the drug. This kills them. Once dead or at least affected by the drug they may just fall out - we hope. If that is so then there should be little problem. They don't usually shrink in size, most likely they have fallen out of the fishes.

It is time to watch the fishes and keep them well fed and active. It is good to watch the group and be ready to change water.

Good luck and keep me informed please. I would appreciate any pictures.

Charles Harrison

Hello Charles,

Thanks for your reply.  I was able to find Levamisole HCI at my local feed store, since I live in a big ranching county in Texas.  On one hand, I wish I had waited to order from you, because your prices are much cheaper than I found in town.  On the other hand, it's worth it to have begun treatment as quickly as possible, I'm not sure she would have held out until the shipment arrived.

I have begun treatment following the directions I found on your web site.  Your instructions here clear up a few points for me, thanks!  Tonight will be 48 hours into treatment.  The infested angel and the other fish in the tank are doing well.  I no longer see the worms protruding from her vent.  I understand that they may have simply withdrawn inside, so the war may not be won.  I will continue treatment per your instructions.

I have been so far unable to get a good shot of the worms.  As you know, they are tiny, and she is fast!  Also, she is in a hex shaped tank, for some reason, that glass distorts my shots.  If I do get a good shot, I will be delighted to send it on to you for use on your web page.

Thanks so much,
Dawn

----- Original Message -----
From: <mailto:charles@inkmkr.com>Charles Harrison
To: Dawn
Sent: Saturday, July 09, 2005 10:31 PM
Subject: Re: camellanus coti emergency!

Dear Charles,

Hello, my name is Dawn and I was sent to you by the fine folks at Badman's Tropical Fish.

 Hello Dawn,

Sorry about the time it has taken me to get back to you.  I am just now getting back to my e-mail.   Regarding your  adult angelfish,  if there are female camellanus worms  protruding - that would indicate that the gut is probably full of the nematodes. That presents quite a problem for the fish once these nematodes are dead.  The fish will have to digest the remains of the dead nematode  or expelled them and that is very difficult for the large intestines to do since it is their primary responsibility to remove water from the feces.  We lose many more fishes to the dead parasite than any other problem.

The nematode may be spread from  tank to tank in many different ways.  It is unfortunate that this parasite is so virulent.  There  doesn't seem to be any treatment available at  the local fish stores.  As a matter of fact most of the local fish store personnel  really has no idea of the problems caused by this parasite.

The treatment for the nematodes is Levamisole HCl,  It is a water soluble compound.  5 grams  treats 100 gal. of water.  You'll want to have enough Levamisole to treat the water twice.  If you have to treat it total of  265 gal. and will probably want to treat it twice, you'll need about 30 gm.  That's gonna cost you $30.00 plus postage.  I don't want you have to chase the nematode around for several months.  The idea is to get control of the environment and manage the problem so you don't have to go back to treat the ailing fish again.

Once you treat the water with the drug and are able to kill off  the parasite, you will need to change the water, all of it.  If you haven't done a 100% water change, now is a good time to get that started.  Many aquarist change only a small portion of the water at a time. If you kill off all lot of parasites, snails, etc. you're going to have quite a bacteria over growth  and the only way to get rid of that is to change all of the water.  So get the fish used to major water changes.

 Another important issue is to keep the fish as healthy as possible.  Live food that the fish enjoy eating will help to push the dead worms through the gut. The medication  actually paralyzes the worms and this causes them to die.  if they remain hooked inside the fish's gut they're going to have to be pushed out & among the best ways to do it as to feed the fish lots of live food.

 OK, what you need to do -  give me your address to send the medication to  and I will  get 30 g  ready to ship to you on Monday.  Since one of your adult Angels  has already died it is quite likely you will not be able to save the  female.  they're just too many animals in the gut that you are going to kill and I don't think she can pass all of them.

 There is one item I would really appreciate from you,  I noticed that you're quite a photographer.  Is there any possible way you could get some pictures of your angelfishes vent and the protruding nematodes?  I have several photographs of many different fishes  but I don't have  any angelfish.

 let me hear back from you.

 Charles H.

I am emailing about my breeding pair of Angels.  I went away on vacation for a week, when I came home the male angel was dead.  Now, looking at the female closely, I see about 8 red things sticking out from her anus.  With help from the folks at Badmans it has been diagnosed at camellanus coti.  I have been told that you can and will give me advice, and that I can buy the medicine from you to try to cure my fish.  I have also been told that I need to treat all of my tanks since this worm can spread by using the same nets and the same python in all my tanks.  I have 10 tanks totalling 265 gallons of water.  One of my 10 gallon tanks has only snails, no fish, do I need to treat them as well?

Please advise me of how much medicine I need, and what the price will be.  I see you accept paypal, so please include their fees in the price.  I'm guessing that I need this med as fast as possible, so please include the fees for the fastest shipping option.

Can she be saved with so many of the worms coming out of her?  Any advice and hand-holding you can give me will be vastly appreciated!

http://www.InkForYourPrinter.com



Re: Levamisole Hydrochloride killed our fish (none / 0) (#19)
by Scott Lockwood on Thu Apr 26, 2007 at 08:19:33 PM PST

Can you look at This and tell me if my math is wrong?

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



That was a confusing discussion. I wasn't sure (none / 0) (#20)
by unclescott on Fri Apr 27, 2007 at 04:45:30 PM PST

where you got your 695 milligrams. The various formulas for mixing up assorted stock solutions lost me too.

I think our confusion was partly in converting ounces into grams into milligrams. Looking back it shouldn’t have been so hard. We muddied the water by adding a set amount of the Levamisole to different quantities of water.

Eventually a couple of us started with Charles's suggested 5 grams for 100 gallons. That easily breaks down into 1 gram for 20 gallons, 1/2 a gram for 10 gallons. Charles himself had previously suggested saving some of the Levamisole by just filling the 10-gallon tank half way and halving that half gram.

You had, I believe 52g, of which 46.8g was pure Levamisole. That is not a whole lot of extra filler.

When miskairal pointed out that a standard teaspoon held 5g, I though, why didn’t I just suggest that you take 10 baggies, put a level teaspoon’s worth in each and maybe one of those jells which pulls moisture from the air in each baggie as well. Then you could use 1/5 or 1/10 of a baggie for your treatment. And what guy has ever measured a LEVEL tablespoon? ;)

Yesterday I needed to mix a certain(eyeballed) amount of sodium thiosulfate to renew my 30-gallon RubberMaid trash is used to declorinate previously bleached equipment. It takes swishing it around in a jar with a little hot water to dissolve most of it. Then I added enough cold water that I could pour that pint into the larger container and it was good to go.I don't know why we got so hung up on those various solutions. Maybe different people  had different quarantine containers around the house.

Oh! And I'll remember that 1 ounce = 28.35 grams or 28,349.5231249 milligrams. That's just the thing to bring up at breakfast. ;)

[ Parent ]



Hey now! (none / 0) (#21)
by Scott Lockwood on Sat Apr 28, 2007 at 08:33:33 AM PST

And what guy has ever measured a LEVEL tablespoon? ;)

Uh, THIS guy, for one! :-)

Remember, I was a lab tech, so being anal retentive goes with the job. That's why this is so distressing to me - I don't want my math error to be responsible for someone else's dead fish! Now mind you, I'm skeptical that it is, but I have taken the precaution of bumping that article back up to the front page, and have put a big warning on it.

Sigh. I wish Charles would weigh in (ba-dump bump) on the issue.

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



Re: Levamisole Hydrochloride killed our fish (none / 0) (#3)
by Scott Lockwood on Wed Apr 25, 2007 at 06:40:40 AM PST

More detail is really needed, but, it sounds to me like you overdosed your fish. What were the water conditions? How recent was your last water change? How bad was the infection?

Personally, having done this dance before, I'd rather over medicate, and retreat in a few days. You've just found out why the hard way.

I'm very sorry about your fish. I hope you don't quit the hobby due to this setback.

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker



Re: Levamisole Hydrochloride killed our fish (none / 0) (#7)
by Katastic01 on Wed Apr 25, 2007 at 08:29:12 AM PST

I just spoke to my husband who is the one that portioned out the medication (I'm not too confident in that area).  I wanted to get the specific details on how much and how he came up with the numbers.  Here's what he said:

The instructions on this site state 695 mg per 10 gal.  For the 30 gal tank I just multiplied by 3 which gives just over 2 grams.  Using the oz measurement from the first page of .027oz per 10 gal gives .081 oz for 30 gal.  If you convert .081 oz to grams by multiplying by 28.35 you come up with 2.296 grams.  That is how we came up with the 2 gram treatment.  Do you believe this is too much for 30 gal?  

[ Parent ]



A tad high but no. You have probably already seen (none / 1) (#9)
by unclescott on Wed Apr 25, 2007 at 09:04:48 AM PST

my speculation about mineral content in your water (which at times I would kill to possess.)

[ Parent ]


Re: A tad high but no. You have probably already s (none / 0) (#11)
by Scott Lockwood on Wed Apr 25, 2007 at 09:28:42 AM PST

Actually, in fish who's health is already severely compromised, it could push them over. I too suspect that it was already too late for other reasons, but OD'ing the fish likely didn't help. Also, it's telling that they basically keeled over once the medication was applied. I suspect that it was the final straw, but that shouldn't minimize the importance of that straw...

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



Re: A tad high but no. You have probably already s (none / 0) (#13)
by Katastic01 on Wed Apr 25, 2007 at 04:27:31 PM PST

I have a question on the OD comments.  Are you saying that the amounts listed here http://www.guppylog.com/story/2006/4/29/164717/627 are incorrect?  The math in those instructions leads to 2+ grams for a 30 gallon tank.  We used 2 grams so I'm not seeing how that was an OD of medication.

Another interesting thing is that only two of the fish acted sick; the rest seemed happy and healthy but we were treating since we figured the infection had spread.


[ Parent ]



Re: A tad high but no. You have probably already s (none / 0) (#16)
by Scott Lockwood on Thu Apr 26, 2007 at 07:50:21 PM PST

Not saying that at all.

What I have said repeatedly is that we need more data about the water in this particular tank.

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



I don't think it is OD-ing. That is by your (none / 0) (#14)
by unclescott on Wed Apr 25, 2007 at 07:33:49 PM PST

figuring just above 2 grams. That is a little stronger than the commercial combos. Charles suggests a timidness by the companies making and dosing pharmaceuticals anyway. With other stuff there seems to be a little flexibility in dosage.

You and your husband were going by a slightly different set of instructions. You were using Lockwood's figures from his exploration of ratios for medication. I was going by Charles' 5 grams per 100 gallons or a gram per every 20 gallons. As a decidedly un-medical person, I simply don't know if the extra half a gram would make too much of a difference.

I notice in re-reading more of the conversations in http://www.guppylog.com/story/2006/4/29/164717/627
that Charles didn't go, in the case he alluded to, for a real long time. He treated for 36 hours, though he planned for 24 hours. He notes that when he re-treated those fish 2 weeks later, he stopped after only 20 hours "as it was VERY stressful on my fish".

Certainly that was still a huge time compared to the 30 awful minutes your fish endured.

So he has had difficulty in one situation too. I do know of other comments in programs where he recommends going a longer than the above case. He doesn't say why his fish were stressed, he just moved them out. So I guess we really need to watch them!

Could you try one obviously infected fish in a smaller container?

I've treated with three different anthelmintics, two in one commercial preparation in some cases. I didn't see the fish all that stressed. But I was treating new fish in a preventative mode (and if they expelled worms, they would probably have been smaller). The other treatments were with Praziquantel for anchor worms which infest gills when small and the fish's skin when large. As they were killed, they would just have fallen off.

Thank you for those water figures. I must have confused them with someone else's. (I owe you big time for that gaff.) Your tap certainly offers hard enough water for guppies. In fact you don't often want to top off evaporation with tap water and let it get continually harder.

And I have the testimony of a couple of people that after a point anthelmintics are hard to dissolve anyway. They vary by chemical.

Scott L's editorial introduction kind of indicated then that he felt that there was overdosing. Later he mentions that he would like to check with a friend at Shedd Aquarium and that he wonders if the issue was overdosing.

I may e-mail a URL of this discussion to Charles. His fish at least one time were awfully stressed too. Both of you removed your fish and their condition improved among the survivors.

If the cause of that wasn't over dosing, was the problem with the reaction of the internal worms and what it was doing to the fish? I don't really know what happened.

You asked about other treatments. For a while Flubendazole was preferred over Levamisole. Then it was unavailable for a time. I have purchased some of that from Charles. He has an ad and an article on that at the bottom of his home page. With the difficulty you have with having to get prescriptions through vets and the prices one must pay, I don't know if I should mention that.

All the best!

[ Parent ]



Re: Levamisole Hydrochloride killed our fish (none / 0) (#5)
by Katastic01 on Wed Apr 25, 2007 at 07:07:20 AM PST

I hope that my last post included enough detail.  Another detail that I forgot to include was that in the last two weeks or so, two of my females had miscarriages.  Is that normal or related to this condition?

[ Parent ]


Sorry about the miscarriages. That certainly isn't (none / 0) (#6)
by unclescott on Wed Apr 25, 2007 at 07:53:46 AM PST

normal. It often here is because someone moved the very pregnant females in their last week or two. See  MY GUPPY FINALLY FINISHED GIVING BIRTH! by Thride

It could have been the treatment, but if I were a betting person I would suggest that the food taken by the Camallanus prevented the fry from developing normally.

If your guppies are able to expel the dead and dying worms, you should find some of the guppies to actually be quite slim. Field studies have show that some adult fish, after a few months, look really healthy and robust but that internal parasites have  destroyed their internal reproductive organs. I hope that is not the case here.

[ Parent ]



I'm sorry about the loss of your fish and that I (none / 1) (#1)
by unclescott on Mon Apr 23, 2007 at 10:25:54 PM PST

didn't see your post over in the log section. You're new and none of us see that a log is a couple to several page treatise on some aspect of the hobby. Short posts are diaries and that is where I look first for emergencies. Also, we are making arrangements to attend to a neighbor couple where one is currently in the hospital this week and the other was in last week.

I would guess that the Levamisole, by itself, wouldn't kill the fish unless it was in the food and was hugely overdosed. I've been lead to believe that anthelmintics are very hard to dissolve beyond a certain point. Indeed some can not really be used for fish. It is probably possible to overdose but not too likely. Your 2 grams for 30 gallons is a little stronger than Charles' "Five grams of Levamisole will treat 100 gallons," but not hugely so. (Most medications have a bit of a fudge factor.)

How big were the Camallanus worms? How long have they been making themselves obvious? Most importantly, have the fish been able to expel the dead and dying worms? If the fish were bloated, that may mean that the worms are still in them. The rotting worms could encourage the rapid multiplication of bacteria, septicemia and gas bloating. And that is so awful!

For constipation, some have recommended adding a level tablespoon of Epsom salts per 10 gallons. I guess that (mostly a magnesium compound) raises the osmotic pressure in the water to closer to the fish's systems.

If they have been able to expel the dying worms, are you able to gravel vacuum them up? Yes if you remove 20% of the water and replace it, you should also replace 20% of the treatment. However that is vastly superior to leaving worms (a very rich meat often) to rot in the tank, to suck up oxygen and to contribute to the over all ammonia load.

Probably this wasn't an issue, but were the fish regurgitating at all? I don't know if they would. They might if fed a lot and then the riot in their  digestive tract took off. I'm personally of the "feed a cold, feed a fever" school. But around fish, during treatment, except for giving them medicated food, feeding should be sparing. That isn't a time you want to worry about left over food.

This is just throwing things again the wall to see if anything sticks, but are there any missing large snails in your tank? In time, anthelminitics can be hard on them. A large dead mystery snail can be disastrous for any fish tank.

Have you kept up with your more or less weekly partial water change (ideally 25-45%)? If the fish are struggling to breath, do you have some treated water, seasoning, which you can add after removing a like portion?

Charles Harrison, who isn't feeding his fish during this time period, recommends a 100% water change with seasoned, treated water of like chemistry and temperature. If that is done quickly, much of the beneficial bacteria on the gravel, "structure" and filter will remain.

On the oxygen front, obviously we want to remove chemical filtering elements (usually activated carbon) but O2 levels are especially important. Is/are the filter(s) and or airstone still running?

Oh, when you say that you cleaned the tank really well, what did that involve? For example, sometimes we clean out filters so well that the floss is white and useless. Then there is much less bacterial breaking down of the ammonia, released by the fish just in their normal respiration.

I don't know if any of these things are of use to you. I would be glad to be wrong because I know each statement sounds so critical. If I've got problems in a tank with parasites, those are among the things I would also ask of myself. And, amazingly dotty as it sounds, if I couldn't figure anything else bothering my fish, I would keep doing partial water changes, even daily if possible.

I have rescued fish from a bad situation occasionally, even though the precise nature of the problem was never effectively identified. Kind of the TLC factor.

Good luck. I fear all aquarists, sooner or later, go through an awful situation such as your.

Over all I'm just as lazy and uninformed as ever. But looking at/ hearing of all the troubles people have from inherited parasites on and in their fish has caused me to try and treat for parasites during the quarantine of any new acquisitions. Time will tell if that makes a difference.



Another probably irrelevant thought. Was there (none / 1) (#2)
by unclescott on Mon Apr 23, 2007 at 10:30:23 PM PST

another medication in there before the Levamisole was added? I have very little understanding of drug interactions, but mixing treatments unless that has been recommended by a qualified veterinarian who has some training or experience with aquarium fish, is a dangerous idea.

Again, I would be glad to be wrong about suggesting the situation.

[ Parent ]



Re: Another probably irrelevant thought. Was there (none / 0) (#4)
by Katastic01 on Wed Apr 25, 2007 at 06:57:31 AM PST

Thank you for your response.  Please forgive me, I am terribly new to fish keeping and this has put a huge damper on things...  Knowing what I know now, I feel awful that this lasted so long.  I thought I had done sufficient research before getting into this.  I apologize for leaving so many open ends, I tried to be very detailed with the situation.    

I guess there have been signs of Camallanus worms for a couple of months now and I was too naive to think there was something wrong.  I'm horribly embarrassed but understand that truthfullness is better for the fish.  Anyhow, a couple of my male guppies got big bellies and died about a month after that symptom started.  Again, I thought it was just a sign of old age.  They never stopped eating and they were very active.  Then one of our newer fish got the prickly worms sticking out of its bottom.  That lasted about a week before I realized that probably wasn't it's normal anatomy and looked into it.  Those worms stuck out about 1/4in.  Just the other day I saw one of our bigger fish expelling what looked like a clump of worms and they were about 1 1/2in long.  The others seem to be eating and pooping pretty normally.

I try to vaccuum about 25-35% of the tank at least once a week.  I also try to get the gravel cleaned as well as I can.  I usually pick up what seems like quite a bit of nasty sediment but no wormy things.  According to my testing, the ammonia levels look perfect.  I don't think there is excessive rotting.

I feed frozen and flake food alternately every day.  I keep to the rule of only feeding what they will eat in a few minutes.  They are always very eager to eat.  I've never seen regurgitating fish other than when they try to take something too big or yucky.

As for feeding while being medicated, they were only in the medicine for about 30 minutes before I took them out of that tank and quickly set up my other tank.  I was scared they would all die if I didn't do that.  They didn't eat in that time period.

I don't have any snails, even the tiny ones, are they recommended in your opinion?

I did add seasoned water after the water change before medicating the fish.  When the carbon was removed the rest of the canister filter was not rinsed or cleaned.  

Before medicating the fish, I removed the carbon filter.  There is and was an air stone moving air in the tank the entire time.

The only medication that I used before this was about a month ago before I knew of this problem.  I treated them for fungus, which cleared up nicely.  I've done a few water changes since then as well as put the carbon filter back in after treatment.  I wouldn't think that there was any medication left related to that.

Do you know of any other medications that may treat this?  I'm worried that this whole thing is going to be too long and painful for the fish.  Especially with such a novice like me.  

Okay, this took me way too long to write  ;)  But I'm trying to be detailed and at the same time have to keep the kids happy.  I never knew that fish would be so involved.  I also didn't realize that something so hard to treat would infect them.  But they are a part of our family and we are dedicated to taking care of them.

[ Parent ]



I really appreciate your reading up and asking (none / 1) (#10)
by unclescott on Wed Apr 25, 2007 at 09:09:58 AM PST

around on the guppies. I speak at aquarium clubs sometimes and I have become convinced that one can never over research a topic. I often start now with "some of you may have forgotten more about this topic than I know, but I hope there will be lot's here new to some of you and at least bits and pieces for the rest." ;)

Don't feel guilty about the worms. They came with a guppy or guppies at sometime. Nobody tells customers. Indeed if the shop moves their stock out in a timely manner, they may have no inkling of the presence of worms in their fish. After a zillion years in the hobby, thanks to Guppylog people who have brought this stuff to my attention, I am finally both quarantining all new acquisitions (even fish from friends) AND giving them a preventative deworming treatment.

I'm finally beginning to understand the depth of what is facing our fish. Wild fish, especially those collected towards the end of the dry season (when water quality is awful and the fish are crowded together - that may sound familiar) and even pond raised fish are exposed to even more parasites and disease organisms than those raised in someone's aquarium. Then they are stressed by getting shipped long distances in close proximity (in the bag) to other fish, put in central filtration systems in wholesaler's and shop or both. I too sometimes lose new fish. Certainly the mortality rate on new fish, for me, is greater than on fish raised here.

There are days I'm surprised anyone is still in the hobby. (But then there are those other glorious days...)

About a year ago my bride and I were in the Detroit area. They have some wonderful shops there. In New Baltimore, MI I spent more on a group of catfish than I ever have before. They were pretty rare - certainly to me. ;)

The shop had quarantined those wild caught fish in the back and fed them well for a month. That costs them utilities, shipping, import license, food,  a deworming/ parasite treatment, labor for water changes and tank space. We often complain about $7 guppy pairs here, but though I was reluctant to part with that much money, I didn't think that $25 each for fish so carefully cared for was at all unfair.

We may not get what we paid for sometimes, but if we don't pay a "reasonable price" we certainly run much lower odds of getting quality or healthy fish.

I'm just delighted that you are operating at the level of sophistication where you are already doing ammonia tests. That is great. I wish every new aquarists would do that.

I do fear that 1/2 hour with the treatment is not enough. That is probably why you have seen no expelled worms. A week to 10 days is probably more on the mark.

Sigh! If you want to get rid of the worms, you will need to try again! Otherwise wait, hope to quickly rescue some fry and hope that they aren't infected when you put them in separate quarters (which may be whistling in the dark) and let the other guppies die of internal munching.

You have struggled through the Camallanus entries in Immediate Help. I have gotten more info from the "Inkmaker" Charles Harrison than anyone else. I know I haven't read and heard all there is on the subject, I'm pretty sure that Charles would say the same.

http://inkmkr.com/Fish/CamallanusTreatment/

I wanted to get back to you on your water. Rainwater is wonderful for breeding rainforest fishes (even useful in cutting water hardness and breeding some "difficult" rainbowfish). Our pollution and the need for demineralized water is why we have the RO (Reverse Osmosis) unit.

But guppies are from waters with some mineral content and a pH above 7. Even a pH of 8 is ok for them. As secondary freshwater fish (meaning that somewhere wayyyy back along the line, even before they evolved from killifish, they have a marine origin. Most, but not all secondary freshwater fishes (such as Poeciliids, killifish, gobies, rainbow fishes, a lot of other Australian freshwater fishes and cichlids) are pretty tolerant of mineral laden water and a bit of sodium chloride.

I have NO hard evidence of this, but I wonder if putting any medication in almost pure rainwater will not dangerously upset the water chemistry. Indeed your guppies are in danger anyway of "Acidosis" from a plunging pH, just as normal biological processes take place. KH or buffering capacity comes from minerals different from the minerals (iron, calcium, magnesium...) which account for hardness. But in nature they are often found together.  (See IH again or Google Acidosis, I.E. "crazy man's" or "crazy fish's disease.")

If the Inkmaker or GuppyMollie or someone else with an understanding of chemistry and aquarium chemistry can respond to this, that would be great.

Would you (Katastic) Google search Guppylog for miskairal and rainwater or just miskairal water? She got away with her rainwater because it sat in a dust filled catchment basin and had a measurable hardness when she finally pulled it out! She also combined it with local stream water sometimes. ;)

You may find that you will want to add some Rift Lake Cichlid Salts to your water until you get a hardness of about 120 to 150 PPM. If you Google DIY (Do It Yourself) cichlid salts you will find some much less expensive recipes which you could mix up. They often involve a little baking soda, and calcium, potassium and magnesium compounds. Some people get away with Marine salts because they do try for many of the 80 minerals and buffers in salt water, but I still think that is too much sodium chloride.)

Add that mix verrrrry gradually to your guppies so they don't shock. I don't even know how much to suggest, maybe 1/5 of the quantity in the fish tank at a time. The next day the same and then begin to walk up the concentration of "mineralized water" until you are at 50%. Do partial water changes with the made up water hereafter.

I would love to elaborate upon this, but must go.

All the best!

[ Parent ]



Re: Another probably irrelevant thought. Was there (none / 0) (#8)
by Scott Lockwood on Wed Apr 25, 2007 at 09:03:39 AM PST

Don't be embarrassed - it's only normal. We all learn, sometimes the hard way. We're here to help!

I'm going to ask a friend who's at the Shedd about the medication levels. My gut feeling is, there's something else going on here as well, but that seems like more than I needed.

Can you get me the water parameters I asked for?

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



Re: Another probably irrelevant thought. Was there (none / 0) (#12)
by Katastic01 on Wed Apr 25, 2007 at 04:19:32 PM PST

Just got my water tested by a pro so that I don't give inaccurate info....

0  Nitrate
0  Nitrite
300 Hardness
0  Chlorine
180 Alkalinity
7.8 PH

And I think there was a misunderstanding in an earlier post.  I only use tap water for our fish.  I do use a dechlorinator so nothing hurts the fish.  My guppies were completely happy and healthy until we set up our new tank and that's when everything went to pot.  I hope these numbers help and are an acceptable level.

[ Parent ]



Also, (none / 0) (#18)
by Scott Lockwood on Thu Apr 26, 2007 at 08:15:20 PM PST

the more I think about this, the more I wonder if you had a sudden rise in the ammonia level. That's about the most stressful thing fish have to deal with, and lots of suddenly dead worms which would excrete any remaining waste they had, plus that would start going south (rotting) while still in the fish... It's just not pretty either way.

Did you just test your water, or did you test the actual water in the tank, before and after?

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



Re: Another probably irrelevant thought. Was there (none / 0) (#17)
by Scott Lockwood on Thu Apr 26, 2007 at 08:05:37 PM PST

Are those 0's accurate? I've never seen a cycled tank with no Nitrate/Nitrites. Were the fish stressed by a recent water change before treatment? The PH is ok, but is perhaps a tad higher than I'd want. The hardness looks okish, but I wonder - does your filter work by deionization? If so, valuable minerals are lost. The water becomes 'hungry'.

I can only guess, since I don't have water or fish corpses to examine, but I think that the sudden shock to the system of killing the worms may have just been too much for the poor little guys. I think your math is a little on the high side, but within norms. I really should make clear that the math I was doing was for my specific tank - you should do your own math every time to make sure you're dosing correctly, don't rely on someone else's figures.

If this happened after only 1/2 an hour of treatment, I can't imaging that it was actually the medication that killed the fish. Where did the water come from that the meds were dissolved in? Was the process of dissolving them simple agitation, or was the solution heated? Blended? Was the water used seasoned? Where did you get the meds, and in what form? Are those water test figures before you put the meds in the tank, or after? The difference between the two could also be telling. What was the medication physically mixed in, and how well was it cleaned? Could there have been any contaminant in the preparation?

We may never know exactly what happened. Sometimes, the best solution is to put down the fish, and bleach everything, dechlorinate it a week later, and start over. It sucks, but it always works. :-(

"I love to visit PetSmart's Tropical Fish Dept. to see what new diseases are around today." -- inkmaker
[ Parent ]



Re: Another probably irrelevant thought. Was there (none / 0) (#22)
by Katastic01 on Mon Apr 30, 2007 at 07:00:21 AM PST

I had the water tested at our LFS so I trusted the numbers were correct.  The kid that did it may  have read/written it incorrectly.  I have a canister filter that just runs the water through sponge and carbon.  It's nothing too fancy.

As for the fish, we made the decision to put them down.  They just aren't doing all that well.  Between the Camallanus and the medication I think it's just been too much for them to live a healthy, normal life.  Especially since the treatment, when done correctly, is very stressful to them.  The expelling of the worms is hard on them, and even if they expel some of the worms, they may not get them all out.  All these things are painful for the fish.  I would rather they go peacefully and quickly than going after a lifetime of pain.  They were good little fish.  

I appreciate all of your time and help.  This was the only place I could go to even begin trying to fix the problem.   No one at the fish stores I went to had even heard of Camallanus.  They either shrugged at me or started telling me to buy a bunch of different medications just hoping one would work.  I was in over my head when this whole thing hit.  I will start over and am going to work closely with our LFS (not Petsmart) to get it done correctly.  I am going to spend today getting the tank torn down and cleaned out.  Maybe my next problem will be finding out who wants guppy fry.  

Thanks again.  I will be checking in daily to read up on the latest news.  

[ Parent ]



I can sure understand your frustration and (none / 0) (#23)
by unclescott on Mon Apr 30, 2007 at 08:44:29 AM PST

sadness of watching those adult guppies struggle so. And we do sometimes have to figure when the cost is way beyond reasonable (sez the man whose wife took a gerbil to the vet's.)

Note that the guppies would have died anyway without treatment. So would have the fry.

I have been wondering about an aged guppy female I was given. She never did drop (rats!), has obviously been aging beyond whem she could have fry and has had her own small tank for months. I toyed with the idea of putting her in a jar with a little dissolved clove oil and anesthetizing her. Evidently a little drinking alcohol is needed to dissolve the clove oil and that is the more often recommended approach these days, though a quick blow to the head (unpalatable for many folks) or leaving the tank out on a very cold night is still ok by Terry Fairfield.

I kept her and even fed her live food the evening before she died Saturday. Her's was such a gorgeous strain (red delta and red-albino delta), that is why I took her in. I do regret that she never dropped.

If your guppy fry were with the adults when they were treated, they should be fine. They probably had tiny, larval Camallanus within them and those should have been successfully treated. You may find fry hard to give away. Most people prefer that you do the work of raising them to a more attractive stage. ;)

If you can do a near tear-down and keep the fry in the tank, they should thrive. (Or tear the tank down, keep the gravel wet and return the fry with some treated, seasoned water. Feed lightly at first. A few growing plants will absorb most ammonia given off by a few fry.) Just add as nearly as much treated and seasoned water as is in there each day or two until it is full. I know that doesn't do your HOB filter much good. Just rinse it out and leave it for now.

And while fry are not nearly as interesting by themselves as adult guppies, they would thrive in a larger aquarium than we many times give them. And there is a wonder in watching them mature.

In a month the females wild begin showing their gravid spots. Not too long afterwards little males will court and pester them. In a couple of months more they will be maturing into adult "millions fish." You may recognize young males reminiscent of those lost. That may salve some of the stress you have gone through recently. After all of the research, work and asking around, you deserve nice things happening in an aquarium. :)

[ Parent ]



Levamisole Hydrochloride killed our fish | 23 comments (23 topical, 0 editorial, 0 hidden)
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