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Levamisole | 8 comments (8 topical, 0 editorial, 0 hidden)
Discomed from Aquatronics (pink package) (none / 0) (#3)
by unclescott on Sat Feb 04, 2006 at 08:03:37 PM PST

contains Levamisole. Levamisole sometimes is marketed as Ergamisole and also is sold by vets as Tramisol. Looking at medicine ingredients on packages can sometimes be surprising.

Do they use it for horses? Perhaps it is under a brand name?

Rzrbkhog (Heidi) gave her "Update on Camallanus" and I got all twitchy about using Fluke Tabs which have the organophosphate, Trichlorofon. Also known as metriphonate, it is dangerous stuff. Of course, so is electricity around fish tanks.

If the anthelmintics are not available, go with the Jungle external parasite treatment. Their internal parasite treatment has an anthelmintic, but it may be Parziquantel. Don’t have it here, but there is probably an organophosphate in there too.  Heck, use Fluketabs, Use any of the antiparasite treatments.

The problem of developing immunities to anthelmintics or organophosphates is not as common as with antibiotics. Maybe (sigh) it actually is beneficial to alternate with those drugs so those squirmy little buggers don't develop an immunity.

Just don't overdose (which you wouldn't do anyway). A story off of the rainbowfish mailing list details how a guy did overdose some fry in the course of a treatment. The organophospate caused their muscles to spasm so badly, they experienced spinal deformities, if the backbones didn't actually break. He had to euthanize the whole batch!

Good luck and death to those Camallanus!
unc

[ Parent ]



Reflections from Charles on the above. (none / 0) (#4)
by unclescott on Mon Feb 06, 2006 at 03:14:03 AM PST

Charles, the Inkmaker, and I have had a bit of a correspondence upon the above. He is certainly the more knowledgeable in terms of many of these things. I have a tad more time today.

He had a feeling that "time" alone will not do the trick of removing the Nematode and the local fish store medications from the various big Tropical Fish Co. s are too afraid of killing off the pets to make their medication strong enough to really do the job of eliminating the parasite. That is comforting in that we and ours are at less risk than we might be from these substances. So, however, might the Camallanus be at less risk that we might want!

Some of you may recall that I left the URL for a badly infected pupfish in the comments associated with the diary "Definitely giving birth, but it's not human!" by rzrbkhog. Heidi described what was going on there and followed it up with "Update on the Camallanus? Saga" where the guppies looked a lot better. The big female seems to have expelled the dead worms, which is a critical juncture in the cure.

However the catfish (Corydoras?) showed great stress and was removed. A Betta was also stressed and treatment stopped. I am unclear on whether the  Betta was in the infected aquarium or not. Also Heidi, was the one you took to school from the infested tank? If the catfish and Betta(s?) were from that tank, they may well have been removed before their worms, should they have had them, were expelled.

There is even a chance that in time they could become carriers at school and if put back in with the guppies and neons. If they were in that Guppy tank. They need treatment. It would make sense to treat them with something containing Levamisole, especially since they were so stressed by the. probably less effective organosulfate.

Both Charles and the owner of that infected pupfish in the jpg are members of the St Louis killies group (SLAKA), but neither of those two are slackers. So they got right to work. ;)

In another note, Charles observed: Recently we started working with this guy (see the pupfish .jpg ) and his tank mates here in St Louis. There were 6 to 8  -  20 to 35 gallon tanks all contaminated more or less with the Nematode. I asked her (the owner of the tanks) to treat everything and we will go back in another 3 weeks and treat all again. The pup fish didn't make it and she lost another 2 or 3 fish which were heavily infected. The deaths are usually to failures to eliminate the dead worms. Other un-infested fish or with just a few worms seem to get through the treatment fine with little or no reaction. A second treatment of medication can be left in the tank for weeks without regard.

The thought the Nematode will die out in a matter of a few days does not meet with much scientific observation. Instead I would suggest that the filaria (another parasitic worm) will molt into a more dormant stage and just wait for warmer weather or other changes in pH or temperature to molt again or just be eaten by a crustacean or fish and then molt again. These Nematodes have a cock roach like motif about themselves. Survivors!!

Just waiting isn't enough to eliminate the nematodes.

I have placed Levamisole in with cultures of Paramecium and other protozoa with no effect. I have corresponded with others who have treated tanks with Flubendazole and not seen all the protozoa wiped out. Don't know which or what survived, but something did. Levamisole will not affect most free living worms. One can mix the drug with Grindals (Grindle worms, a food worm smaller that whiteworms or the yet larger blackworms) and feed the wiggling mess to fish for treatment. It doesn't seem to affect microworms in tank water although I understand they are Nematodes . . .

The fish keeper here in St Louis with the afflicted Pup Fish has remarked on how specific the Levamisole is toward the Camallanus
Nematode leaving so many other things alone. She is a medical Ph D!

    Perhaps dosage or time of treatment may change these things, but this is the present state of affairs. I have found nothing which is so specific and certain as Levamisole toward the Camallanus cotti. Off the shelf products in Canada and from many of my contacts here in the US,  the UK and Australia have been ineffectual in killing the Nematode.

So wraith, in light of all of this, you were wise in going with the Levamisole for the Camallanus. (PeterW is lurking and nodding, "Yep!") Heidi, you are correct in that your fish will not look like that one in the photo. It is a different species of parasitic worm. However your Camallanus case may not be over, especially in the instances of the Betta and Catfish.

Now I'd better go see what the heck this filaria stuff is. (ah - Filaria medinensis, a parasitic nematode from Central America which can effect both fish and people. Don't drink the water!)

This is all pretty heavy for this early in the morning! :)

All the best!
unc

[ Parent ]



Re: Reflections from Charles on the above. (none / 0) (#5)
by wraith on Mon Feb 06, 2006 at 12:16:51 PM PST

I have 3 tanks that I am going to treat as I have fish in each tank from my originally infected tank.
10G - 5 guppies
10G - 5 guppies, 4 black stripe tetras, and 1 peppered cory
20G - 7 guppies, 2 yoyo loaches, 1 african dwarf frog.
All 3 of my tanks have live plants in with fake ones.
Your mention of a catfish and betta that did not seem to do well with the treatment worries me a little. I am now concerned for all the little creatures I have in my tanks and for my plants. Will levamisole affect them? has anyone had any other experience with small fish other than guppies and this medication?
I will try it in the tanks anyways, and watch for signs of stress in all the fish and my frog.

thanks for all the info,

cheers!

[ Parent ]



The other fish should respond much like the (none / 0) (#6)
by unclescott on Mon Feb 06, 2006 at 12:39:52 PM PST

guppies. In one of the earlier GL discussions of Camallanus (probably in IH) I alluded to a frog site which noted that the African frogs were vulnerable to Camallanus. What astonished me was they were talking about C cotti, the same one which infects tropical fish! I assumed it would be another species.

Naturally when the question of infected frogs came up again, I couldn't find the URL or article. I would assume though that it is necessary that they be treated.

The plants should be fine. They should be clear of any swimming Camallanus. Leave the light on during treatment for the same time period as before, so the plants' environment doesn't change.

Good luck and all the best!

unc

[ Parent ]



Re: The other fish should respond much like the (none / 0) (#7)
by wraith on Mon Feb 06, 2006 at 04:54:30 PM PST

I know that the frogs and everything else I have are susceptible to camallanus, what I'm worried about is levamisole. How do they respond to the drug itself? Everyone survived medicating the first time with the jungle parasite removal, but if this drug is stronger, I am wondering if anyone has seen the side affects of it on other fish and such.
In the meantime, I will begin treatment as soon as I get the levamisol and will just keep a close eye on everyone!
Another thought. I know I will need to bleach out and scrub everything down again. How contagious, if at all, is this worm to humans? I have 2 children, and although they just look at the tank, I can't guarantee that they won't put their little fingers in there sometimes!

Thanks so much!
cheers!


[ Parent ]



If the levamisole indeed kills the Camallanus, (none / 0) (#8)
by unclescott on Tue Feb 07, 2006 at 02:39:02 AM PST

do a good job of siphoning the gravel. Then leave the siphon out in the weather. There should be no need to tear down and bleach the tank if the nematodes are killed. The Camallanus are livebearers abd though there are egg-laying nematodes such as the one Charles and that physician are dealing with in St. Louis, I don't think Camallanus has the capacity to rest as eggs and cysts. Burgess has suggested in several places that the free swimming larvae must find a host or die within a day or two.

The recommended second treatment by Charles is a surprise to me, but designed to be really sure the wee beasties are gone. Charles' recommendation that it be left in the tank, until cycled out with water changes should do it in.

Maybe I'm too confident that the Levamisole works. But the bleach wouldn't get the surviving worms in that most all of them would be within the fish anyway.

I do appreciate your concern with children and the fish tank. They do need to be kept out of suspect tanks and that can be easier said than done sometimes. Witness angelhologram's Bad Santa diary from yesterday. Keeping fingers out of mouths is not easy either. (I remember reading in an essay by John Steinbeck that the average American child had injested three bushals of dirt in the course of growing up!.)

The Filaria which was the other situation in St Louis, is a much more serious case. I really hope that doesn't get around the hobby.

All the best!
u.s.

[ Parent ]



Levamisole | 8 comments (8 topical, 0 editorial, 0 hidden)
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